Russell B Lingham Selected Research

Hypoxia-Inducible Factor-Proline Dioxygenases

12/2016	Discovery of N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia.
4/2012	1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia.

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Russell B Lingham Research Topics

Disease

2	Insulin Resistance 01/2018 - 01/2017
2	Anemia 12/2016 - 04/2012
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2021
1	Glucose Intolerance 01/2018
1	Type 2 Diabetes Mellitus (MODY) 01/2017
1	Hyperglycemia 01/2017
1	Hyperinsulinism (Hyperinsulinemia) 01/2017
1	Hypoxia (Hypoxemia) 12/2016
1	HIV Infections (HIV Infection) 02/2003
1	Neoplasms (Cancer) 03/2002

Drug/Important Bio-Agent (IBA)

2	Insulin ReceptorIBA 01/2018 - 01/2017
2	Monoclonal AntibodiesIBA 01/2018 - 01/2017
2	Hypoxia-Inducible Factor-Proline DioxygenasesIBA 12/2016 - 04/2012
2	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 12/2016 - 04/2012
1	AutoantibodiesIBA 01/2021
1	DNA (Deoxyribonucleic Acid)IBA 01/2021
1	Blood Glucose (Blood Sugar)IBA 01/2018
1	Insulin (Novolin)FDA Link 01/2018
1	Glucose (Dextrose)FDA LinkGeneric 01/2017
1	Glucagon-Like Peptide-1 ReceptorIBA 01/2017
1	Exenatide (Byetta)FDA Link 01/2017
1	bis(4- methoxyphenyl)methyl)- 4- hydroxy- 2- (pyridazin- 3- yl)pyrimidine- 5- carboxamideIBA 12/2016
1	decaneIBA 04/2012
1	EnzymesIBA 04/2012
1	Human immunodeficiency virus 1 p31 integrase proteinIBA 02/2003
1	TransferasesIBA 03/2002
1	Proteins (Proteins, Gene)FDA Link 03/2002

Therapy/Procedure

1	Glycemic Control 01/2018
1	Therapeutics 01/2017